A review on spherical crystallization: A novel technique in the field of particle engineering

In the production of tablets, direct compression method is mostly used. comparison to traditional wet granulation approach, this cannot be used with sensitive pharmaceuticals and also has a lot more processing limitations. Spherical agglomeration novel for creating pharmaceutical dosage forms that are immediately compressible, process spherical agglomeration, which improves powder's qualities such as particle size, shape, flow characteristics, solubility, bioavailability medicinal ingredients, includes transforming tiny crystals into shape. The crystallization was improved use hydrophilic polymers in order improve dissolution properties poorly water-soluble. size analysis, compression, behaviour agglomerates were improved. Wet (WSA) quasiemulsion solvent diffusion (QESD) two most methods crystallizing spheres. Additionally, these approaches have additions: ammonia system (ADS) crystallo-coagglomeration (CCA).The neutralization technique another procedure. Any aforementioned can employed simultaneously both agglomeration. crystal physical including their polymorphism detection using x-ray powder diffraction (XRD), thermodynamic characteristics differential scanning calorimetry (DSC), examined.